Samurai Champloo, Kyo Kara Maoh, Pretear, Fruits Basket, Full Metal Alchemist, Ghost in the Shell, InuYasha, Chobits, I could go on forever lol
Most of you should be familiar with almost all of these but I imagine none, or very few, have ever watched Kyo Kara Maoh, Fruits Basket or Pretear. If you haven't, you're doing yourself a great disservice.